{"id":22584,"date":"2025-12-03T08:51:23","date_gmt":"2025-12-03T05:21:23","guid":{"rendered":"https:\/\/irsa.clinic\/?p=22584"},"modified":"2026-10-21T15:02:18","modified_gmt":"2026-10-21T11:32:18","slug":"pdlla-and-plla-fillers-for-lasting-rejuvenation","status":"publish","type":"post","link":"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/","title":{"rendered":"Skin Boosters and PDLLA and PLLA Biological Fillers: the Magic of Lasting Rejuvenation in 2026"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">In recent years, the field of skin rejuvenation and correction of facial lines and sagging has rapidly moved from purely volumizing methods to collagen promoters and biocompatible materials. Two names that have become very prominent in this direction are PDLLA and PLLA; soluble and collagen-stimulating polymers that are injected into the skin in the form of fillers or specific mesotherapy.<\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 ez-toc-wrap-right counter-flat ez-toc-counter-rtl ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">\u0641\u0647\u0631\u0633\u062a \u0645\u0637\u0627\u0644\u0628<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#What_is_PDLLA_and_how_does_it_work\" >What is PDLLA and how does it work?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Mechanism_and_scientific_evidence\" >Mechanism and scientific evidence<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Practical_applications\" >Practical applications<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Important_point\" >Important point<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#What_is_PLLA_and_how_is_it_different_from_PDLLA\" >What is PLLA and how is it different from PDLLA?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Main_difference_with_PDLLA\" >Main difference with PDLLA<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Practical_applications-2\" >Practical applications<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#General_advantages_of_Skin_boosters_and_biological_fillers_such_as_PDLLA_and_PLLA_in_Iran\" >General advantages of Skin boosters and biological fillers such as PDLLA and PLLA in Iran<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#a_Natural_and_acceptable_appearance\" >a) Natural and acceptable appearance<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#b_Longer-lasting_than_some_short-term_fillers\" >b) Longer-lasting than some short-term fillers<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#c_Ability_to_be_combined_with_other_methods\" >c) Ability to be combined with other methods<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#d_Reduce_the_possibility_of_an_unnatural_or_uneven_appearance\" >d) Reduce the possibility of an unnatural or uneven appearance<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Suitable_people_for_PDLLA_and_PLLA_fillers_in_Shiraz\" >Suitable people for PDLLA and PLLA fillers in Shiraz<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Safety_tips_and_possible_side_effects\" >Safety tips and possible side effects<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#a_Side_effects_reported_in_PLLA\" >a) Side effects reported in PLLA<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#b_Possible_side_effects_of_PDLLA\" >b) Possible side effects of PDLLA<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#c_General_tips_for_reducing_risk\" >c) General tips for reducing risk<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#PDLLA_and_PLLA_Treatment_Process_%E2%80%94_What_to_Expect\" >PDLLA and PLLA Treatment Process \u2014 What to Expect?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#1_Consultation_and_Evaluation_Session\" >1. Consultation and Evaluation Session<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#2_Initial_Injection\" >2. Initial Injection<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#3_Follow-up_and_Observation_Period\" >3. Follow-up and Observation Period<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#4_Sessions_with_Greater_Effect\" >4. Sessions with Greater Effect<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#How_to_Choose_Between_PDLLA_and_PLLA_at_Irsa_clinic_in_Iran\" >How to Choose Between PDLLA and PLLA at Irsa clinic in Iran?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Factors_influencing_the_choice\" >Factors influencing the choice<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#The_best_doctor_for_PLLA_and_PDLLA_rejuvenation_injections_in_Shiraz\" >The best doctor for PLLA and PDLLA rejuvenation injections in Shiraz<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Criteria_for_choosing_the_best_doctor_for_PLLA_PDLLA_injections\" >Criteria for choosing the best doctor for PLLA \/ PDLLA injections<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#1_Official_course_and_certificate_in_biostimulator_training\" >1. Official course and certificate in biostimulator training<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#2_Practical_experience_in_deep_and_collagen-forming_injections\" >2. Practical experience in deep and collagen-forming injections<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#3_Real_and_verifiable_portfolios\" >3. Real and verifiable portfolios<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#4_Use_original_and_approved_products\" >4. Use original and approved products<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#5_Accurate_and_honest_consultation_before_injection\" >5. Accurate and honest consultation before injection<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#6_Safe_and_standardized_treatment_environment\" >6. Safe and standardized treatment environment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#What_is_Skin_booster_and_how_is_it_different_from_PDLLAPLLA\" >What is Skin booster and how is it different from PDLLA\/PLLA?<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Differences\" >Differences<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Combined_use\" >Combined use<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Profhilo_and_Jalupro_and_their_differences_from_PDLLAPLLA\" >Profhilo and Jalupro and their differences from PDLLA\/PLLA<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Conclusion_and_final_recommendations\" >Conclusion and final recommendations<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Key_points_for_decision-making\" >Key points for decision-making<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Further_reading\" >Further reading<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/irsa.clinic\/en\/pdlla-and-plla-fillers-for-lasting-rejuvenation\/#Important_Reminder\" >Important Reminder<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\">In addition, terms such as &#8221; skin booster are also used for products that are a combination of collagen-stimulating, moisturizing, and skin tissue-strengthening substances. The overall goal of all these methods is to achieve firmer, fresher skin, with fewer lines and a more natural appearance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This article aims to fully introduce these materials, how they work, their differences, advantages, disadvantages, and safety tips so that both applicants and beauty professionals can make a more informed decision.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-pdlla-and-how-does-it-work\"><span class=\"ez-toc-section\" id=\"What_is_PDLLA_and_how_does_it_work\"><\/span>What is PDLLA and how does it work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PDLLA stands for Poly-D, L-Lactic Acid, a biodegradable polymer that has been used in various forms in medicine and beauty in recent years. Its main advantage is its ability to stimulate collagen production and tissue regeneration, not just immediate space-filling.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-mechanism-and-scientific-evidence\"><span class=\"ez-toc-section\" id=\"Mechanism_and_scientific_evidence\"><\/span>Mechanism and scientific evidence<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PDLLA has been introduced in review and research studies as a soluble and collagen-stimulating biological material. Scientific studies show that PDLLA can increase skin elasticity and firmness, reduce fine lines and wrinkles, and repair tissue. This was stated in a 2024 therapeutic review published in Dermatology.<\/li>\n\n\n\n<li>In the same review, PDLLA was noted to provide significant improvements in skin rejuvenation, scar repair, and tissue elasticity due to its unique structure and high biocompatibility. These findings are supported by various clinical studies.<\/li>\n\n\n\n<li>Study samples have reported improved firmness, hydration, and reduction of fine lines with PDLLA; even in hands or areas of the body with loose skin or wrinkles.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-practical-applications\"><span class=\"ez-toc-section\" id=\"Practical_applications\"><\/span>Practical applications<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Use on facial areas to reduce fine lines and increase skin firmness<\/li>\n\n\n\n<li>Strengthening hand tissue or areas with moderate sagging and sagging<\/li>\n\n\n\n<li>Combination with other methods such as hyaluronic acid or PRP to enhance the effect<\/li>\n\n\n\n<li>Repairing scars or areas with tissue problems<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-important-point\"><span class=\"ez-toc-section\" id=\"Important_point\"><\/span>Important point<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PDLLA, unlike instant volumizing fillers that only add volume, is a collagen-stimulating and tissue-regenerating product, and its results usually appear over weeks to months. Don\u2019t expect an instant miracle like a bulking filler; it\u2019s a gradual, sustained process.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_is_PLLA_and_how_is_it_different_from_PDLLA\"><\/span>What is PLLA and how is it different from PDLLA?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"706\" src=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-2-1024x706-1.jpg\" alt=\"What is PLLA and how is it different from PDLLA?\" class=\"wp-image-22585\" style=\"width:655px\" srcset=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-2-1024x706-1.jpg 1024w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-2-1024x706-1-300x207.jpg 300w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-2-1024x706-1-768x530.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">PLLA, or Poly-L-Lactic Acid, is another biopolymer that has been used in medicine for years and is known in aesthetics as a collagen builder. Compared to PDLLA, PLLA has a longer history in some applications, but both fall into the family of biologic promoters.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A controlled study on the use of PLLA showed that this material was significantly effective in improving cheek lines and wrinkles, with high patient satisfaction, a natural appearance, and a lasting effect over a 12-month period. In this study, more than 90% of participants reported improvements in skin radiance and firmness, and no significant side effects were reported.<\/li>\n\n\n\n<li>Other reviews of PLLA have also shown that this material is useful in various areas of the face and body for volume enhancement, firmness, and sagging correction, and its uses outside the face are also expanding.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-main-difference-with-pdlla\"><span class=\"ez-toc-section\" id=\"Main_difference_with_PDLLA\"><\/span>Main difference with PDLLA<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both are collagen stimulators, but have different chemical structures; as a result, there may be slight differences in tissue response and speed of effect.<\/li>\n\n\n\n<li>There is more clinical experience and statistics about PLLA in the world, and in some areas, more well-known commercial models are used (such as Sculptra as a commercial example of PLLA in some countries).<\/li>\n\n\n\n<li>PDLLA has shown more innovation in new research, especially in combination studies or connection with other materials, and is gaining a strong position in the market and research.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-practical-applications-0\"><span class=\"ez-toc-section\" id=\"Practical_applications-2\"><\/span>Practical applications<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Correction of deep or moderate lines on the face<\/li>\n\n\n\n<li>Improvement of sagging and reduction of wrinkles with long-term effect<\/li>\n\n\n\n<li>Increase in thickness and overall quality of the skin in areas with thin or thin tissue<\/li>\n\n\n\n<li>Use in treatments that require a natural result, not too bulky<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-pullquote has-white-color has-text-color has-background has-link-color wp-elements-1\" style=\"background-color:#115171\"><blockquote><p><strong> Skin rejuvenation with Platelet-Rich Plasma in Iran<\/strong><\/p><cite><strong><a href=\"https:\/\/irsa.clinic\/en\/face-prp\/\" type=\"link\" id=\"https:\/\/irsa.clinic\/en\/face-prp\/\">Face PRP<\/a><\/strong><\/cite><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-general-advantages-of-skin-boosters-and-biological-fillers-such-as-pdlla-and-plla-in-iran\"><span class=\"ez-toc-section\" id=\"General_advantages_of_Skin_boosters_and_biological_fillers_such_as_PDLLA_and_PLLA_in_Iran\"><\/span>General advantages of Skin boosters and biological fillers such as PDLLA and PLLA in Iran<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The main goal of these materials is natural rejuvenation along with reducing complications and unnaturalness. In this section, we will discuss the key benefits.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-a-natural-and-acceptable-appearance\"><span class=\"ez-toc-section\" id=\"a_Natural_and_acceptable_appearance\"><\/span>a) Natural and acceptable appearance<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 These materials stimulate collagen, causing gradual tissue regeneration. The result is not bulky and artificial, but soft, natural and harmonious with the facial features.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-b-longer-lasting-than-some-short-term-fillers\"><span class=\"ez-toc-section\" id=\"b_Longer-lasting_than_some_short-term_fillers\"><\/span>b) Longer-lasting than some short-term fillers<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 PLLA studies have shown that the effect can last for about a year or sometimes longer, depending on the number of sessions and injection technique. This means less need for repeated injections than some short-term gels.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-c-ability-to-be-combined-with-other-methods\"><span class=\"ez-toc-section\" id=\"c_Ability_to_be_combined_with_other_methods\"><\/span>c) Ability to be combined with other methods<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 PDLLA has been shown to have a synergistic effect when combined with hyaluronic acid or other strengthening and restorative methods. This allows a multi-stage and customized treatment plan to be designed for each individual.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-d-reduce-the-possibility-of-an-unnatural-or-uneven-appearance\"><span class=\"ez-toc-section\" id=\"d_Reduce_the_possibility_of_an_unnatural_or_uneven_appearance\"><\/span>d) Reduce the possibility of an unnatural or uneven appearance<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Because these materials are biological and create volume by building collagen, there is less chance of creating a severe bulge or an unnatural shape, provided the injection technique is performed correctly.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our suggestion to you: The best hair loss treatment doctor in Shiraz<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-suitable-people-for-pdlla-and-plla-fillers-in-shiraz\"><span class=\"ez-toc-section\" id=\"Suitable_people_for_PDLLA_and_PLLA_fillers_in_Shiraz\"><\/span>Suitable people for PDLLA and PLLA fillers in Shiraz<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1024\" height=\"706\" src=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-3-1024x706-1.jpg\" alt=\"Suitable people for PDLLA and PLLA fillers in Shiraz\" class=\"wp-image-22588\" style=\"width:655px\" srcset=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-3-1024x706-1.jpg 1024w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-3-1024x706-1-300x207.jpg 300w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-3-1024x706-1-768x530.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Not every cosmetic procedure is suitable for everyone. Knowing the target groups will help you make a better choice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Suitable for:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>People with fine to moderate lines if they want to maintain a natural appearance.<\/li>\n\n\n\n<li>Those who are more focused on overall skin rejuvenation and firmness than specific volume.<\/li>\n\n\n\n<li>First-time applicants or those who have had a history of volumizing fillers but were not satisfied with the unnatural effect.<\/li>\n\n\n\n<li>People who want to require fewer re-injections in the long term and get more lasting results.<\/li>\n\n\n\n<li>Those seeking to repair scars or damaged areas of the skin, especially in situations where tissue quality improvement is more important than immediate volume.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-safety-tips-and-possible-side-effects\"><span class=\"ez-toc-section\" id=\"Safety_tips_and_possible_side_effects\"><\/span>Safety tips and possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Any substance injected into the body has the potential for side effects; the goal is to reduce the likelihood and severity of these side effects by recognizing them and, if they occur, to control and treat them.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-a-side-effects-reported-in-plla\"><span class=\"ez-toc-section\" id=\"a_Side_effects_reported_in_PLLA\"><\/span>a) Side effects reported in PLLA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Studies and reviews have shown that PLLA is generally well tolerated, but cases of short-term and rare side effects have been reported: pain, swelling, bleeding, bruising, discoloration, and in very rare cases, inflammatory or granuloma-like reactions. These side effects usually resolve within 1\u20132 weeks. In some rare cases, delayed granulomatous or persistent nodules have been reported that required long-term treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 These cases are controllable with specialist selection, correct technique, and follow-up. It is important to inform the patient about the possibility of occurrence and to follow up carefully after injection.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-b-possible-side-effects-of-pdlla\"><span class=\"ez-toc-section\" id=\"b_Possible_side_effects_of_PDLLA\"><\/span>b) Possible side effects of PDLLA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Scientific reviews of PDLLA point to the possibility of similar side effects, such as nodule or granuloma formation, which, of course, are less likely to occur with improper dosage and technique, and excessive inflammation. Studies emphasize the need for monitoring and prompt intervention in case of problems.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 It is recommended to have injections in reputable centers, with a doctor or specialist with sufficient experience and training.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-c-general-tips-for-reducing-risk\"><span class=\"ez-toc-section\" id=\"c_General_tips_for_reducing_risk\"><\/span>c) General tips for reducing risk<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Choose a reputable clinic and the best rejuvenation filler injection doctor in Shiraz who is trained and experienced in PDLLA and PLLA injection techniques and, in addition, uses a quality and original product.<\/li>\n\n\n\n<li>Follow pre- and post-injection instructions: avoid using thinning medications without consultation, do not massage or apply unnecessary pressure to the area, watch for infection, promptly report any unusual changes.<\/li>\n\n\n\n<li>Control realistic expectations: PDLLA and PLLA results usually appear in a few months; Patience and follow-up help to see better and more lasting results.<\/li>\n\n\n\n<li>Planning for follow-up sessions and, if necessary, appropriate intervals between subsequent sessions.<\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-pullquote has-white-color has-text-color has-background has-link-color wp-elements-2\" style=\"background-color:#115171\"><blockquote><p><strong>Miracle of skin rejuvenation at Irsa clinic in Iran <\/strong><\/p><cite><a href=\"https:\/\/irsa.clinic\/en\/fotona-laser-treatment-advantage-and-disadvantage\/\" type=\"link\" id=\"https:\/\/irsa.clinic\/en\/fotona-laser-treatment-advantage-and-disadvantage\/\">Fotona laser: Treatment, advantage, and disadvantage<\/a><\/cite><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pdlla-and-plla-treatment-process-what-to-expect\"><span class=\"ez-toc-section\" id=\"PDLLA_and_PLLA_Treatment_Process_%E2%80%94_What_to_Expect\"><\/span>PDLLA and PLLA Treatment Process \u2014 What to Expect?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Understanding what happens during and after the process can help reduce stress and provide confidence.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-1-consultation-and-evaluation-session\"><span class=\"ez-toc-section\" id=\"1_Consultation_and_Evaluation_Session\"><\/span>1. Consultation and Evaluation Session<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Review of skin condition, medical history, expectations, and goals<\/li>\n\n\n\n<li>Selection of appropriate material, dosage, and injection site<\/li>\n\n\n\n<li>Explanation of timing of effects and possible side effects<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-2-initial-injection\"><span class=\"ez-toc-section\" id=\"2_Initial_Injection\"><\/span>2. Initial Injection<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Injections at specific intervals and points according to the doctor\u2019s technique<\/li>\n\n\n\n<li>Possible mild pain or burning sensation during injection<\/li>\n\n\n\n<li>Minimal swelling or bruising at the injection site<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-3-follow-up-and-observation-period\"><span class=\"ez-toc-section\" id=\"3_Follow-up_and_Observation_Period\"><\/span>3. Follow-up and Observation Period<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Full effects may appear in a few weeks to a few months, depending on the material and the body\u2019s response<\/li>\n\n\n\n<li>In the case of PDLLA or PLLA, injections may be repeated in several sessions, at specific intervals, to achieve optimal results<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-4-sessions-with-greater-effect\"><span class=\"ez-toc-section\" id=\"4_Sessions_with_Greater_Effect\"><\/span>4. Sessions with Greater Effect<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Some people receive desirable and lasting effects after 2\u20133 sessions over a period of one to two years<\/li>\n\n\n\n<li>The number of sessions may vary in different areas of the body<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-to-choose-between-pdlla-and-plla-at-irsa-clinic-in-iran\"><span class=\"ez-toc-section\" id=\"How_to_Choose_Between_PDLLA_and_PLLA_at_Irsa_clinic_in_Iran\"><\/span>How to Choose Between PDLLA and PLLA at Irsa clinic in Iran?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1024\" height=\"706\" src=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-4-1024x706-1.jpg\" alt=\"How to Choose Between PDLLA and PLLA at Irsa clinic in Iran?\" class=\"wp-image-22591\" style=\"width:655px\" srcset=\"https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-4-1024x706-1.jpg 1024w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-4-1024x706-1-300x207.jpg 300w, https:\/\/irsa.clinic\/wp-content\/uploads\/2026\/07\/pdlla-plla.jpg-4-1024x706-1-768x530.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Choosing between two closely related materials requires consideration of several factors; not only scientific background, but also individual conditions, treatment goals, and the doctor&#8217;s experience.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-factors-influencing-the-choice\"><span class=\"ez-toc-section\" id=\"Factors_influencing_the_choice\"><\/span>Factors influencing the choice<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The main goal of the treatment: Is it just to remove lines or to repair extensive tissue?<\/li>\n\n\n\n<li>The doctor&#8217;s experience in working with PDLLA or PLLA, and previous results in similar patients<\/li>\n\n\n\n<li>Availability of the product and guaranteed quality (authenticity, storage conditions)<\/li>\n\n\n\n<li>Cost and number of sessions required: There may be differences depending on the type of material and the body&#8217;s response.<\/li>\n\n\n\n<li>Compatibility with the individual&#8217;s life plan: timing of the effect, closure or restrictions after the injection, need for further visits<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-best-doctor-for-plla-and-pdlla-rejuvenation-injections-in-shiraz\"><span class=\"ez-toc-section\" id=\"The_best_doctor_for_PLLA_and_PDLLA_rejuvenation_injections_in_Shiraz\"><\/span>The best doctor for PLLA and PDLLA rejuvenation injections in Shiraz<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When choosing the best doctor for PLLA and PDLLA rejuvenation injections, it is better to decide based on reliable criteria because these types of injections are biostimulators and require skill, specialized training, and detailed knowledge of anatomy. Below, I have written the most important criteria that will help you make a confident choice:<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-criteria-for-choosing-the-best-doctor-for-plla-pdlla-injections\"><span class=\"ez-toc-section\" id=\"Criteria_for_choosing_the_best_doctor_for_PLLA_PDLLA_injections\"><\/span>Criteria for choosing the best doctor for PLLA \/ PDLLA injections<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-1-official-course-and-certificate-in-biostimulator-training\"><span class=\"ez-toc-section\" id=\"1_Official_course_and_certificate_in_biostimulator_training\"><\/span>1. Official course and certificate in biostimulator training<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The doctor must have completed accredited courses related to biological fillers, including PLLA and PDLLA. These fillers have a more sensitive injection technique than hyaluronic acid, and professional training is essential. In this regard, Dr. Mostafa Emadi, as one of the accredited and expert doctors in this field, with real satisfaction from his beauty seekers, can be a reliable choice to experience this service.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-2-practical-experience-in-deep-and-collagen-forming-injections\"><span class=\"ez-toc-section\" id=\"2_Practical_experience_in_deep_and_collagen-forming_injections\"><\/span>2. Practical experience in deep and collagen-forming injections<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The doctor&#8217;s skill in recognizing injection layers, high-risk areas, and managing possible complications is the main factor in the final result and your safety.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-3-real-and-verifiable-portfolios\"><span class=\"ez-toc-section\" id=\"3_Real_and_verifiable_portfolios\"><\/span>3. Real and verifiable portfolios<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Viewing real Before\/After shows that the doctor has sufficient expertise in creating a natural result that suits the shape of the face.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-4-use-original-and-approved-products\"><span class=\"ez-toc-section\" id=\"4_Use_original_and_approved_products\"><\/span>4. Use original and approved products<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Fake or unverified biological fillers have serious risks. A reputable doctor always uses brands with CE or FDA standards.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-5-accurate-and-honest-consultation-before-injection\"><span class=\"ez-toc-section\" id=\"5_Accurate_and_honest_consultation_before_injection\"><\/span>5. Accurate and honest consultation before injection<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A professional doctor will talk to you clearly without exaggeration about the real need, number of sessions, duration and reasonable expectations.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-6-safe-and-standardized-treatment-environment\"><span class=\"ez-toc-section\" id=\"6_Safe_and_standardized_treatment_environment\"><\/span>6. Safe and standardized treatment environment<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Biostimulator injections should be performed in an official clinic, with a standard sterile protocol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-skin-booster-and-how-is-it-different-from-pdlla-plla\"><span class=\"ez-toc-section\" id=\"What_is_Skin_booster_and_how_is_it_different_from_PDLLAPLLA\"><\/span>What is Skin booster and how is it different from PDLLA\/PLLA?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sometimes the term Skin booster or gel mesotherapy is used for products that contain a combination of biocompatible and tissue-strengthening substances; it may include hyaluronic acid, vitamins, antioxidants, or even controlled amounts of collagen-stimulating substances.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-differences\"><span class=\"ez-toc-section\" id=\"Differences\"><\/span>Differences<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PDLLA\/PLLA: The main focus is on collagen production and tissue regeneration using specific polymers.<\/li>\n\n\n\n<li>Skin booster: May be a combination; some formulas for rapid hydration, some for brightening, some for moderate collagen stimulation.<\/li>\n\n\n\n<li>PDLLA\/PLLA typically have a stronger and longer-lasting effect on skin tightening and improving quality compared to some Skin boosters that have a faster and shorter effect or a combination.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-combined-use\"><span class=\"ez-toc-section\" id=\"Combined_use\"><\/span>Combined use<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In many cases, the doctor may combine PDLLA\/PLLA in one area and Skin booster in another area or in a different session to enhance the effect and achieve optimal results.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-profhilo-and-jalupro-and-their-differences-from-pdlla-plla\"><span class=\"ez-toc-section\" id=\"Profhilo_and_Jalupro_and_their_differences_from_PDLLAPLLA\"><\/span>Profhilo and Jalupro and their differences from PDLLA\/PLLA<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Profilo and Jalupro both fall into the group of \u201chydrating and rejuvenating biostimulators\u201d, but their function and formula have important differences. Profhilo contains a very high concentration of stabilized hyaluronic acid, which, without creating artificial volume, provides deep hydration, improves skin texture and gently stimulates collagen production. The result is a fresh, firm and even texture. In contrast, Jalupro is a combination of amino acids and light hyaluronic acid that has a more nourishing role and is very effective for repairing tired skin, under the eyes, superficial wrinkles and age spots. In short, Profilo is more powerful and effective for overall rejuvenation, while Jalpro is a more subtle and gentle treatment for skin rejuvenation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But PDLLA and PLLA fillers fall into a completely different category; they are \u201cdeep collagen biostimulators\u201d that work more like skin lifting and structural reconstruction treatments. Instead of hydrating, these materials stimulate cells to produce new collagen, producing results such as a gentle lift, natural volume, filling in deep lines, and improving facial contours. Their effects appear later (2-3 months after injection) but are much longer lasting (12-24 months). While Profilo and Jalpro are suitable for those looking for rejuvenation, skin repair, and deep hydration, PDLLA\/PLLA fillers are suitable for those who want deep, long-lasting lifting, skin tightening, and rejuvenation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-conclusion-and-final-recommendations\"><span class=\"ez-toc-section\" id=\"Conclusion_and_final_recommendations\"><\/span>Conclusion and final recommendations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Using PDLLA, PLLA or biological Skin boosters for rejuvenation promises natural, lasting results with less risk than more extreme methods; provided that they are performed with awareness, precision and the right choice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In fact, biological fillers are fillers with low volume and high stimulation of collagen production. The most common types of them include PLLA (known as Sculptra) and PDLLA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In general, both types do not create much volume, but PLLA has more volume and durability than PDLLA. The durability of PLLA is usually between two and three years, while the durability of PDLLA is about one and a half to two years.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In terms of time of effect, PDLLA produces results sooner and is usually visible about three weeks after injection, but PLLA usually shows its effect one to two months later. However, the volume of PDLLA is less than PLLA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PDLLA is suitable for people who do not want to add a lot of volume and are more interested in improving the quality of the skin. This filler has very good results, especially in the treatment of acne scars, and increases collagen production, improves skin texture and transparency.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One of the important advantages of PDLLA is that after injection, it acts like a scaffold for the skin. This means that other treatments after it, such as thread lift, Profilo injection or other Skin boosters, will be more effective and the results of skin rejuvenation will be much better.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Be careful that if you want more volume, you should use regular gels; because regular gels have more filling and volumizing properties. Of course, it is usually recommended to first volumize the desired area with gel and, if necessary, use PDLLA in the next step for collagen production.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In comparison, PDLLA competes more with Profilo Structura. The main difference between the two is in the cost and number of sessions. Structura usually requires two initial sessions one month apart and then a reminder session after six months to a year; that is, at least three sessions per year, which is expensive at current prices. In contrast, PDLLA is performed in one session and is much more cost-effective in terms of cost and durability.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Profilos mainly have hydrating properties and do not create a specific volume. However, due to the restoration of subcutaneous fat tissue, sometimes a slight feeling of volume is created after Profilo injections. Their collagen production rate is low, because they are classified as hydrogels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In contrast, PDLLA creates very little volume (about 20%) but has the highest rate of collagen production, resulting in natural skin lifting. For this reason, the changes created with PDLLA in rejuvenation are very natural.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-key-points-for-decision-making\"><span class=\"ez-toc-section\" id=\"Key_points_for_decision-making\"><\/span>Key points for decision-making<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Set a personal goal: What do you want to correct or enhance?<\/li>\n\n\n\n<li>Consult an experienced specialist: Review the area, appropriate material, technique, and number of sessions<\/li>\n\n\n\n<li>Realistic expectations: Gradual and natural effect; not a sudden change<\/li>\n\n\n\n<li>Follow safety guidelines: Choose a reputable center, follow up after the injection, and be aware of possible side effects<\/li>\n\n\n\n<li>Monitor product quality: Use approved materials or materials with a proven scientific background and documented clinical experience<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">With this approach, PDLLA and PLLA can be well placed in the rejuvenation treatment portfolio and improve skin shaping, strengthening, and beauty on several levels\u2014childlike and natural, not bulky and confined.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-further-reading\"><span class=\"ez-toc-section\" id=\"Further_reading\"><\/span>Further reading<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2024 Scientific Review of PDLLA in Dermatology Applications; References to the effects of collagen formation and tissue regeneration. MDPI<\/li>\n\n\n\n<li>Controlled clinical study on PLLA showing high satisfaction and long-term effect. PubMed<\/li>\n\n\n\n<li>Comprehensive review of PLLA applications in different body areas. PMC<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-important-reminder\"><span class=\"ez-toc-section\" id=\"Important_Reminder\"><\/span>Important Reminder<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The content of this article is for informational and educational purposes and cannot replace professional medical advice. Before any cosmetic or therapeutic procedure, especially with biological materials, it is necessary to consult a specialist doctor and ensure the qualifications, history, and standards of the clinic or treatment center.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Finally, for a completely free professional consultation and to book an in-person appointment with a doctor at the Irsa Hair and Eyebrow Transplantation Specialized Clinic, contact our experienced consultants by calling the landline numbers listed on the Contact Us page or by mobile phone and WhatsApp number 00989170626693.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Get your free consultation with Irsa team right here<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">WhatsApp: 00989170626693<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Email: irsaarabic@gmail.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">www.youtube.com\/@irsaclinic<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">www.facebook.com\/irsaclinic<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Also read:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/irsa.clinic\/en\/blepharoplasty\/\">Upper eyelid blepharoplasty<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/irsa.clinic\/en\/abdominoplasty-tummy-tuck-in-iran\/\">Abdominoplasty or tummy tuck in Iran<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/irsa.clinic\/en\/skin-mesotherapy\/\">What is Skin Mesotherapy?<\/a><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"DRzrbOa3kD\"><a href=\"https:\/\/irsa.clinic\/en\/hair-transplant-surgery\/\">Hair Transplant Surgery<\/a><\/blockquote><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Hair Transplant Surgery&#8221; &#8212; \u06a9\u0644\u06cc\u0646\u06cc\u06a9 \u067e\u0648\u0633\u062a\u060c \u0645\u0648 \u0648 \u0632\u06cc\u0628\u0627\u06cc\u06cc \u0627\u06cc\u0631\u0633\u0627\" src=\"https:\/\/irsa.clinic\/en\/hair-transplant-surgery\/embed\/#?secret=I0CR8n3BCW#?secret=DRzrbOa3kD\" data-secret=\"DRzrbOa3kD\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<div style='text-align:center' class='yasr-auto-insert-visitor'><\/div>","protected":false},"excerpt":{"rendered":"<p>In recent years, the field of skin rejuvenation and correction of facial lines and sagging has rapidly moved from purely volumizing methods to collagen promoters and biocompatible materials. Two names that have become very prominent in this direction are PDLLA and PLLA; soluble and collagen-stimulating polymers that are injected into the skin in the form [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":21648,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[103],"tags":[],"class_list":["post-22584","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-skin-and-hair-health-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Skin Boosters and PDLLA and PLLA Biological Fillers| Irsa Clinic<\/title>\n<meta name=\"description\" content=\"Skin Boosters and PDLLA and PLLA Biological Fillers: The Magic of Lasting 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